Steroid injections are a common treatment option for a variety of medical conditions, including arthritis, asthma, and allergic reactions. However, there is a growing concern about the potential side effect of weight gain associated with these injections. While some individuals have reported significant weight gain after receiving steroid injections, others have not experienced any changes in their weight. In this article, we will explore the question of can one steroid injection cause weight gain?
We will also discuss the factors that contribute to weight gain with steroid injections. We will also examine the risks and benefits of steroid injections and provide recommendations for individuals considering this treatment option.
How do Steroid Injections Work?
Steroid injections are a form of medication that is injected directly into the affected area of the body. These injections contain synthetic forms of the hormone cortisol, which is naturally produced by the adrenal glands.Â
Cortisol plays a crucial role in the body’s response to stress and inflammation, as it helps to regulate the immune system and reduce inflammation.
The purpose of steroid injections is to reduce inflammation and pain in specific areas of the body.

The injections work by suppressing the immune system’s response to inflammation and reducing the production of certain chemicals that contribute to inflammation. This helps to relieve pain and improve mobility in the affected area.
When a steroid injection is administered, the medication is absorbed into the bloodstream and transported to the affected area of the body.
Once the medication reaches the targeted area, it is taken up by the cells in that area and begins to exert its anti-inflammatory effects.
Steroid injections can be given in a variety of ways, including intramuscularly (into a muscle), subcutaneously (under the skin), and intra-articularly (into a joint).Â
The method of administration will depend on the specific medical condition being treated and the location of the affected area.
Can One Steroid Injection Cause Weight Gain?
The answer to whether one steroid injection can cause weight gain is not a straightforward one. While it is possible for individuals to experience weight gain as a side effect of steroid injections, the severity of weight gain can vary depending on several factors.
- Dosage: The dosage of the steroid injection can play a role in weight gain. Higher doses of steroids have been linked to greater weight gain, while lower doses may have little to no effect on weight.
- Frequency: The frequency of steroid injections can also contribute to weight gain. Receiving frequent injections over a short period of time can increase the risk of weight gain as the body may not have enough time to metabolize and eliminate the steroids before the next injection is administered.
- Individual factors: Individual factors, such as age, gender, genetics, and lifestyle, can also play a role in weight gain with steroid injections. Older individuals may be more susceptible to weight gain due to changes in metabolism, while women may be more likely to experience weight gain due to hormonal factors.
- Lifestyle factors: Lifestyle factors, such as diet and exercise habits, can also contribute to weight gain with steroid injections. Individuals who consume a high-calorie diet or have a sedentary lifestyle may be more likely to experience weight gain as a side effect of steroid injections.
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Do Steroid Injections Cause Weight Gain?
While steroid injections are a popular treatment for a variety of medical conditions, there is evidence to suggest that they can cause weight gain as a potential side effect. Several studies have investigated the relationship between steroid injections and weight gain.
For example, a study published in the Journal of Clinical Rheumatology found that patients who received steroid injections for joint pain experienced an average weight gain of 4.4 pounds over a six-month period.
Another study published in the Journal of Bone and Joint Surgery found that patients who received steroid injections for back pain gained an average of 6.6 pounds over a 12-month period.

Risks and Benefits of Steroid Injections
Steroid injections have both potential risks and benefits, which should be carefully considered before beginning treatment.
- Benefits: The primary benefit of steroid injections is their ability to reduce inflammation and pain in specific areas of the body. This can be particularly beneficial for individuals with conditions such as arthritis, back pain, and joint pain. Steroid injections can also be used to treat allergic reactions and certain skin conditions.
- Risks: One of the most significant risks of steroid injections is the potential for side effects, including weight gain, increased blood sugar levels, and weakened bones. Additionally, steroid injections can suppress the immune system, which can increase the risk of infections. In rare cases, steroid injections can also cause more severe side effects, such as nerve damage, spinal cord injury, or allergic reactions.
- Short-term effects: The short-term effects of steroid injections can include temporary pain relief and improved mobility in the affected area. However, these effects may only last for a few weeks to a few months, depending on the individual and the medical condition being treated.
- Long-term effects: The long-term effects of steroid injections are less clear and can depend on a variety of factors, including the frequency and dosage of injections, as well as individual factors. Some studies suggest that long-term use of steroids can increase the risk of certain medical conditions, such as osteoporosis and diabetes.
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Conclusion
In conclusion, steroid injections can be an effective treatment for a variety of medical conditions, but they can also come with potential risks and side effects, including weight gain.
While weight gain is not always a harmful or unwanted side effect, individuals should discuss the potential risks and benefits of steroid injections with a qualified healthcare professional before beginning treatment and closely monitor their weight and lifestyle habits to minimize the risk of weight gain.
Ultimately, the decision to use steroid injections should be made on an individual basis, with careful consideration of the potential risks and benefits.
FAQS
Can steroid injections cause weight gain in everyone who receives them?
No, not everyone who receives a steroid injection will experience weight gain. The severity of weight gain can depend on individual factors and the specifics of the treatment.
Is weight gain a harmful side effect of steroid injections?
Weight gain is not always a harmful or unwanted side effect, as some individuals may require weight gain for medical reasons. However, excessive weight gain can increase the risk of other medical conditions and should be closely monitored.
How can individuals minimize the risk of weight gain with steroid injections?
Individuals can minimize the risk of weight gain by maintaining a healthy diet and exercise routine, avoiding high-calorie foods and drinks, and discussing the potential risks and benefits of steroid injections with a qualified healthcare professional.
What are some other potential side effects of steroid injections?
Other potential side effects of steroid injections can include increased blood sugar levels, weakened bones, immune system suppression, and in rare cases, nerve damage or spinal cord injury.
Are steroid injections safe for everyone?
Steroid injections may not be safe for everyone, particularly those with certain medical conditions or who are taking certain medications. It is important to discuss the potential risks and benefits of steroid injections with a qualified healthcare professional before beginning treatment.
References
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- Saag KG, Teng GG, Patkar NM, et al. American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis. Arthritis Rheum. 2008;59(6):762-784. doi:10.1002/art.23721
- Wong M, Man REK, Fenwick EK, et al. The Effects of Intra-Articular Corticosteroids on Glucose Metabolism in Diabetic Patients: A Systematic Review and Meta-analysis. Diabetes Ther. 2019;10(2):463-481. doi:10.1007/s13300-019-0587-9
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- American Society of Anesthesiologists Task Force on Chronic Pain Management; American Society of Regional Anesthesia and Pain Medicine. Practice guidelines for chronic pain management: an updated report by the American Society of Anesthesiologists Task Force on Chronic Pain Management and the American Society of Regional Anesthesia and Pain Medicine. Anesthesiology. 2010;112(4):810-833. doi:10.1097/ALN.0b013e3181c43103