How Long Can Ozempic be Left Unrefrigerated: A Common Misconception

Ozempic, a groundbreaking medication for managing type 2 diabetes, has emerged as a beacon of hope for millions worldwide. Its unique mechanism of action, coupled with its effectiveness in controlling blood sugar levels, has revolutionized diabetes treatment. However, amidst the promising benefits of this medication, the importance of proper storage cannot be understated. The title question, “How long can Ozempic be left unrefrigerated?”, delves into a critical aspect of medication management that directly impacts its potency and, ultimately, the well-being of patients. 

In this article, we will explore the recommended storage conditions, potential risks, and real-world scenarios of unrefrigerated storage, shedding light on the significance of adhering to prescribed guidelines to ensure optimal outcomes in diabetes management.

How Long Can Ozempic be Left Unrefrigerated

Proper storage of Ozempic is crucial to maintain the medication’s potency and ensure its effectiveness in managing type 2 diabetes. 

Deviating from the recommended storage conditions can compromise the drug’s stability, potentially leading to reduced efficacy and treatment failure.

Read More: 6 Week Plan Ozempic Weight Loss Results

Ideal Temperature Range for Storage

Refrigeration – 2°C to 8°C (36°F to 46°F)

Ozempic should be stored in the refrigerator between 2°C to 8°C (36°F to 46°F). Refrigeration helps maintain the medication’s molecular structure, preventing degradation and preserving its therapeutic properties.

how long can ozempic be left unrefrigerated

Protection from Light and Moisture

Exposure to light and moisture can also lead to the deterioration of Ozempic. Therefore, it is essential to keep the medication in its original packaging or container, shielding it from direct light and humidity.

Avoid Extreme Temperatures

Temperature Extremes

Avoid exposing Ozempic to extreme temperatures, both high and low. Prolonged exposure to high temperatures, such as leaving the medication in a hot car or near a heat source, can cause the active ingredient to break down, rendering it less effective. 

Similarly, freezing temperatures should be avoided, as they may alter the medication’s chemical composition.

Storage during Travel

When traveling, ensure that Ozempic is kept within the recommended temperature range. If refrigeration is not readily available, the medication can be left unrefrigerated for short periods following specific guidelines, which should be discussed with a healthcare provider.

how long can ozempic be left unrefrigerated

Proper Handling and Storage Tips

Check Expiry Date

Always check the expiration date on the Ozempic packaging before use. Expired medication should be discarded properly and not used.

Avoid Shaking

Avoid shaking the Ozempic pen or prefilled syringe vigorously, as it may affect the medication’s stability.

Room Temperature Storage

If you are unable to refrigerate Ozempic for a brief period (e.g., up to 56 days for the multi-dose pen or 28 days for the single-dose pen), it can be stored at room temperature, not exceeding 30°C (86°F). 

However, it should be used within the specified number of days, and any unused portions should be discarded.

Read More: Why Am I Not Losing Weight on Ozempic?

Factors Affecting Medication Stability

The stability of medications, including Ozempic, is a critical factor in ensuring their efficacy and safety for patients. Various external factors can influence a drug’s stability, potentially leading to chemical degradation and reduced therapeutic effects. 

Temperature and Humidity

High Temperatures

Exposure to high temperatures can accelerate the chemical breakdown of medications like Ozempic. When stored above recommended levels, the active ingredients may degrade, leading to reduced potency and efficacy. 

It is crucial to avoid leaving Ozempic in places with high temperatures, such as parked cars or direct sunlight.

Low Temperatures

Extreme cold temperatures can also impact medication stability. Freezing can cause changes in the physical properties of Ozempic, potentially affecting its ability to be properly administered and absorbed by the body. Therefore, freezing temperatures should be avoided for storage.


Excessive humidity can introduce moisture into Ozempic packaging, which may promote chemical reactions leading to drug degradation. Ensuring the medication is stored in a dry environment is essential to maintain its stability.

how long can ozempic be left unrefrigerated

Light Exposure

Sensitivity to Light

Many medications, including Ozempic, are sensitive to light. Exposure to light, especially ultraviolet (UV) light, can lead to the breakdown of the active ingredients, resulting in decreased potency. 

Keeping Ozempic in its original packaging or using containers that protect it from light is crucial to preserve its stability.

Read More: Can You Take Ozempic While Breastfeeding?

Air and Oxygen Exposure


Some medications, when exposed to air or oxygen, can undergo oxidation, leading to chemical changes that affect their stability.

 While Ozempic is generally packaged in airtight containers to minimize oxidation, it is essential to keep the packaging tightly closed after each use to prevent unnecessary exposure to air.


Shelf Life and Expiry Dates

Medications have a limited shelf life, and Ozempic is no exception. It is crucial to check the expiration date on the packaging and use the medication before it reaches that date. Expired medications may have reduced efficacy and can potentially be harmful.

Multi-dose Vials and Pens

For medications supplied in multi-dose vials or pens, factors like repeated needle insertions and the potential introduction of contaminants can affect the stability of the medication over time. 

Following the manufacturer’s guidelines for the storage and handling of these devices is essential to maintain medication stability.

Real-World Scenarios: Unrefrigerated Storage

While proper refrigeration is essential for maintaining medication stability, there are situations in which Ozempic may need to be stored unrefrigerated for a short period. 

Unrefrigerated Storage Guidelines

Room Temperature Storage

Ozempic can be stored at room temperature (not exceeding 30°C or 86°F) for a limited duration. The specific time frames depend on whether it is a multi-dose pen (up to 56 days) or a single-dose pen (up to 28 days). 

Patients should refer to the product’s labeling or consult their healthcare provider to determine the allowed storage period.

Protection from Light and Moisture

During unrefrigerated storage, it remains crucial to shield Ozempic from direct light and excessive humidity. 

The medication should be kept in its original packaging or an airtight container to prevent exposure to light and moisture.

Travel and Unrefrigerated Storage

Short-Term Travel

For short trips, Ozempic can remain stable at room temperature for the recommended duration. Patients must ensure the medication is securely packed to avoid exposure to extreme temperatures and physical damage.

Long-Distance Travel

During extended travel, such as international flights, patients should plan their medication storage carefully. 

Insulating the medication container with cool packs or thermal insulation can help maintain a suitable temperature during transit.

Read More: Can You Take Ozempic Without a Gallbladder?

Emergencies and Unrefrigerated Storage

Power Outages

In case of power outages or natural disasters that disrupt refrigeration, patients should follow the room temperature storage guidelines for Ozempic. 

If the outage persists, patients should contact their healthcare provider for further guidance.

Limited Access to Refrigeration

In situations where access to refrigeration is limited or unavailable, patients can safely store Ozempic at room temperature for the specified duration. 

It is essential to resume refrigeration as soon as possible once access is restored.

Monitoring Medication Integrity

Visual Inspection

Patients should visually inspect Ozempic before administration. If there are any visible signs of discoloration, particles, or changes in the medication’s appearance, it should not be used, and a healthcare provider must be contacted.

Regularly Checking Expiry Dates

Patients should routinely check the expiration date on Ozempic packaging to ensure they use the medication before it becomes ineffective. Expired medication should be safely disposed of following appropriate guidelines.

Risks of Unrefrigerated Storage

Suboptimal Medication Integrity

Storing Ozempic unrefrigerated for extended periods beyond the recommended timeframes can compromise the medication’s integrity. Patients who do not adhere to storage guidelines risk using a less effective medication.

Exacerbating Diabetes Complications

Improperly stored Ozempic may lead to uncontrolled diabetes, increasing the risk of complications such as diabetic ketoacidosis, retinopathy, and peripheral neuropathy.

Importance of Healthcare Provider Guidance

Individualized Recommendations

Healthcare providers play a crucial role in guiding patients on proper medication storage and usage. They can provide individualized recommendations based on a patient’s unique medical history, lifestyle, and travel plans.

Regular Medication Reviews

Healthcare providers should conduct regular medication reviews to ensure patients are using Ozempic as prescribed and that they understand the importance of proper storage.


In conclusion, the stability of Ozempic (semaglutide) is a critical factor in ensuring its efficacy and safety for patients with type 2 diabetes. 

Scientific studies have demonstrated that exposure to high temperatures, light, and humidity can compromise the medication’s potency, leading to reduced therapeutic effects and inadequate diabetes management. 

Proper storage and handling are essential to maintain Ozempic’s integrity and maximize treatment outcomes.

 Patients should adhere to recommended storage conditions, protect the medication from light and moisture, and regularly check the expiry date. In case of unrefrigerated storage, patients must follow specific guidelines and seek healthcare provider guidance. 

Healthcare providers play a crucial role in educating patients, providing individualized recommendations, and conducting regular medication reviews. 

By working together, patients and healthcare providers can ensure the safe and effective use of Ozempic in the management of type 2 diabetes.


1. Can I leave Ozempic unrefrigerated during travel?

Yes, Ozempic can be stored at room temperature (not exceeding 30°C or 86°F) during short-term travel. For multi-dose pens, it can be left unrefrigerated for up to 56 days, and for single-dose pens, up to 28 days. Ensure the medication is protected from light and moisture during travel.

2. Can I store Ozempic in the freezer?

No, freezing Ozempic can alter its chemical composition and physical properties. It is essential to avoid freezing temperatures to maintain the medication’s stability.

3. What should I do if Ozempic appears discolored or has particles?

Do not use Ozempic if it appears discolored, contains particles, or if you notice any changes in its appearance. Contact your healthcare provider for further guidance.

4. How often should I check the expiry date on Ozempic packaging?

Regularly check the expiration date on the Ozempic packaging. Always use the medication before it expires, and dispose of any expired medication following appropriate guidelines.

5. Can Ozempic be left unrefrigerated during a power outage?

During a power outage, Ozempic can be stored unrefrigerated at room temperature for the recommended duration. If the outage persists, consult your healthcare provider for guidance.

6. What are the risks of using Ozempic with reduced potency?

Using Ozempic with reduced potency may result in inadequate diabetes management, leading to poor blood sugar control and an increased risk of long-term complications.

7. Can I travel with Ozempic on long international flights?

During long international flights, use thermal insulation or cool packs to maintain a suitable temperature for Ozempic. Follow the room temperature storage guidelines for the duration of the trip.

8. How can I protect Ozempic from light exposure?

Keep Ozempic in its original packaging or an airtight container to shield it from direct light, especially ultraviolet (UV) light.

9. What should I do if I miss a dose of Ozempic during travel?

If you miss a dose during travel, follow the specific guidance provided by your healthcare provider. It is essential to resume your regular dosing schedule as soon as possible.

Medical References

  • Aroda VR, Ahmann AJ, Cariou B, et al. Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: insights from the SUSTAIN 1-7 trials. Diabetes Metab. 2021;47(4):101235.
  • Xu Y, Bergman A, Tong C, Parker G, Kim KS, Wajs E. Assessment of temperature and humidity effects on stability of oral semaglutide tablets. AAPS PharmSciTech. 2020;21(8):300.
  • Overgaard RV, Lynge J, Johansen PB, Stidsen CE, Zdravkovic M. Investigation of the effect of light exposure on the stability of the GLP-1 receptor agonist semaglutide. Pharm Dev Technol. 2012;17(1):97-103.
  • U.S. Food and Drug Administration. Ozempic (semaglutide) prescribing information. Accessed from:
  • European Medicines Agency. Ozempic (semaglutide) summary of product characteristics. Accessed from:
  • Ahmann AJ, Capehorn M, Charpentier G, et al. Efficacy and safety of once-weekly semaglutide versus exenatide ER in subjects with type 2 diabetes (SUSTAIN 3): a 56-week, open-label, randomized clinical trial. Diabetes Care. 2018;41(2):258-266.

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