Can Menopause Cause Peripheral Neuropathy?

Menopause, a natural phase in a woman’s life, signifies the end of reproductive years, usually occurring around the age of 50. It brings with it a unique set of experiences, from hot flashes to mood swings. However, an often-overlooked aspect of menopause is whether can menopause cause peripheral neuropathy.

Peripheral neuropathy is a condition where the nerves that transmit signals from our brain and spinal cord to the rest of the body are affected, causing symptoms like tingling, numbness, and pain in the extremities. 

In this article we will throw light on the possible relationship of menopause and peripheral neuropathy. 

What is Menopause?  

Menopause is the point in time when a woman has not experienced a menstrual period for 12 consecutive months. 

It typically occurs between the ages of 45 and 55, with the average age being around 51. During menopause, a woman’s ovaries gradually reduce their production of the hormones estrogen and progesterone, leading to the end of fertility.

Common Menopausal Symptoms  

During menopause, women often experience a range of symptoms due to hormonal fluctuations. These can include:

1. Hot Flashes and Night Sweats  

Hot flashes are sudden, intense sensations of heat that often affect the face, neck, and chest. Night sweats are similar, but they occur during sleep, leading to night awakenings and discomfort.

can menopause cause peripheral neuropathy

2. Mood Changes  

Many women experience mood swings, irritability, and even symptoms of depression or anxiety during menopause. 

Hormonal changes can influence neurotransmitters in the brain, affecting mood.

Read More: How Long Does Menopause Last After Total Hysterectomy?

3. Sleep Disturbances  

Sleep problems, including insomnia and waking up frequently during the night, are common during menopause. 

These disruptions can lead to fatigue and daytime drowsiness.

4. Vaginal Changes  

Lower estrogen levels can result in vaginal dryness, itching, and discomfort during sexual intercourse. 

These changes can impact sexual health and relationships.

Can Menopause Cause Peripheral Neuropathy?

Menopause is a complex phase marked by hormonal changes in a woman’s body. While it is primarily associated with symptoms like hot flashes and mood swings. 

Researchers have been investigating whether menopause could also be linked to peripheral neuropathy, a condition affecting the peripheral nervous system. Let’s delve into this potential connection:

1. What is Peripheral Neuropathy?  

Peripheral neuropathy is a condition characterized by damage to the nerves outside the brain and spinal cord

These peripheral nerves play a crucial role in transmitting signals between the central nervous system and the rest of the body. 

When damaged, they can cause a range of symptoms, such as tingling, numbness, burning sensations, and muscle weakness.

2. Common Symptoms  

Symptoms of peripheral neuropathy can vary widely but may include:

  • Tingling and Numbness: A sensation of pins and needles or loss of feeling.
  • Burning Pain: A persistent, burning sensation, often in the hands or feet.
  • Muscle Weakness: Difficulty in moving and controlling muscles.
  • Balance Problems: Difficulty maintaining balance and coordination.
  • Sensitivity to Touch: Some people may become hypersensitive to touch.

The Potential Link Between Menopause and Peripheral Neuropathy  

1. Hormonal Changes  

During menopause, the body experiences a significant decrease in estrogen levels. Estrogen has a protective effect on nerve health and can influence nerve function. 

The drop in estrogen levels could potentially affect the peripheral nerves, making them more vulnerable to damage.

can menopause cause peripheral neuropathy

2. Other Factors  

Besides hormonal changes, menopause often brings other factors into play:

  • Age: The risk of peripheral neuropathy increases with age, and menopause typically occurs as women get older.
  • Metabolic Changes: Menopause can lead to metabolic changes, including alterations in blood sugar levels, which may affect nerve function.
  • Lifestyle Factors: Lifestyle choices such as smoking and alcohol consumption, which can exacerbate neuropathy, may also change during menopause.

Risk Factors for Peripheral Neuropathy during Menopause  

1. Age  

  • Factor: Aging is a primary risk factor for peripheral neuropathy.
  • Explanation: As women go through menopause, they naturally age, increasing their susceptibility to nerve-related conditions.

2. Hormonal Changes  

  • Factor: Hormonal fluctuations during menopause, particularly the decrease in estrogen levels.
  • Explanation: Estrogen, a hormone that plays a role in nerve health, may offer protection to peripheral nerves. Its decline could potentially contribute to nerve damage.

3. Metabolic Factors  

  • Factor: Altered metabolism and blood sugar fluctuations.
  • Explanation: Menopause can lead to changes in glucose metabolism, potentially affecting nerve function. Elevated blood sugar levels can also contribute to neuropathy.

4. Lifestyle Choices  

  • Factor: Unhealthy habits like smoking and excessive alcohol consumption.
  • Explanation: These habits can exacerbate nerve damage and should be addressed or minimized to reduce the risk of peripheral neuropathy.

Read More: How to Boost Immune System during Menopause?

Prevention Strategies  

1. Regular Health Checkups  

  • Strategy: Schedule regular checkups with your healthcare provider.
  • Explanation: Routine checkups allow for early detection of any signs or symptoms of peripheral neuropathy. Timely intervention can prevent further nerve damage.

2. Maintain a Healthy Lifestyle  

  • Strategy: Adopt a balanced diet and engage in regular exercise.
  • Explanation: A well-balanced diet and physical activity can help control blood sugar levels, support overall health, and reduce the risk of neuropathy.

3. Limit Alcohol and Quit Smoking  

  • Strategy: Reduce alcohol consumption and seek support to quit smoking.
  • Explanation: These lifestyle changes can minimize factors that contribute to nerve damage and improve overall well-being.

4. Manage Underlying Conditions  

  • Strategy: Manage conditions such as diabetes and hypertension.
  • Explanation: Properly managing underlying health conditions can prevent complications that may lead to peripheral neuropathy.

5. Consult a Specialist  

  • Strategy: Seek guidance from a neurologist or a healthcare specialist.
  • Explanation: If you experience symptoms of peripheral neuropathy or have risk factors, consult a healthcare professional for evaluation, diagnosis, and tailored management.


In conclusion, the relationship between menopause and peripheral neuropathy is a subject of growing interest and importance. 

Menopause, marked by hormonal changes and age-related factors, may indeed influence the development of peripheral neuropathy. 

Understanding the potential connection is crucial, as it can aid in early detection and appropriate management, ultimately improving the quality of life for women going through this significant life transition.

As we’ve explored, peripheral neuropathy can manifest with symptoms like tingling, numbness, burning pain, muscle weakness, and balance issues. 

Factors such as age, hormonal changes, metabolic alterations, and lifestyle choices can increase the risk. 

However, proactive steps like regular health checkups, a healthy lifestyle, and management of underlying conditions can help prevent or mitigate the effects of peripheral neuropathy during menopause.

Remember, if you suspect you may have peripheral neuropathy or experience concerning symptoms, seeking medical advice from a specialist is essential for accurate diagnosis and personalized care.

Frequently Asked Questions (FAQs)

1. Can menopause cause peripheral neuropathy?  

  • Answer: Menopause may increase the risk of peripheral neuropathy due to hormonal changes and aging, but it’s not a direct cause.

2. What are the common symptoms of peripheral neuropathy?  

  • Answer: Common symptoms include tingling, numbness, burning pain, muscle weakness, and balance problems.

3. Are there any preventive measures for peripheral neuropathy during menopause?  

  • Answer: Yes, preventive measures include regular checkups, a balanced diet, exercise, limiting alcohol, quitting smoking, and managing underlying conditions.

4. How does age affect the risk of peripheral neuropathy during menopause?  

  • Answer: Aging is a primary risk factor, as the likelihood of peripheral neuropathy increases with age, coinciding with the menopausal period.

5. What role do hormonal changes play in peripheral neuropathy during menopause?  

  • Answer: Hormonal fluctuations, particularly the decrease in estrogen, may affect nerve health and contribute to peripheral neuropathy.

6. Can peripheral neuropathy during menopause be reversed?  

  • Answer: Depending on the underlying cause, some cases of peripheral neuropathy can be managed and symptoms improved, but complete reversal may not be possible.

7. Should I see a specialist if I suspect peripheral neuropathy during menopause?  

  • Answer: Yes, consulting a neurologist or a healthcare specialist is essential for accurate diagnosis and tailored management.

8. What other conditions can mimic the symptoms of peripheral neuropathy?  

  • Answer: Conditions such as vitamin deficiencies, autoimmune disorders, and nerve entrapment syndromes can mimic peripheral neuropathy symptoms and should be considered during evaluation.

9. Can lifestyle changes really reduce the risk of peripheral neuropathy during menopause?  

  • Answer: Yes, adopting a healthy lifestyle, including a balanced diet and regular exercise, can help control blood sugar levels and support overall nerve health, reducing the risk of neuropathy.

Medical References

  • Callaghan BC, Price RS, Feldman EL. Distal Symmetric Polyneuropathy: A Review. JAMA. 2015;314(20):2172-2181.
  • Albers JW, Pop-Busui R. Diabetic neuropathy: mechanisms, emerging treatments, and subtypes. Curr Neurol Neurosci Rep. 2014;14(8):473.
  • Brinton RD. Neuroprotective and regenerative actions of estrogen: basic mechanisms and clinical implications. Steroids. 2008;73(9-10):927-930.

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